ODCs

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2 OMIM references -
2 associated genes
8 signs/symptoms

PROTEIN INTERACTIONS: 1

1 associated gene
4 signs/symptoms

X-linked lymphoproliferative disease

Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease

SH2D1A	(UniProt - OMIM)		KIT	(UniProt - OMIM)
XIAP	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	SH2D1A	(0.72)	KIT

Citations in the biomedical literature:

X-linked lymphoproliferative disease		Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease
	Synonym(s): - Duncan disease - Purtilo syndrome - XLP		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare immune disease - Rare oncologic disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: x-linked recessive		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: adulthood Average age of death: - Type of inheritance: sporadic

	External references: 2 OMIM references - 1 MeSH reference: D008232		External references: No OMIM references No MeSH references

X-linked lymphoproliferative disease		Systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease
	Very frequent - T-cell deficiency / cellular immunity deficiency - X-linked recessive inheritance Frequent - Agammaglobulinemia / hypogammaglobulinemia / B-cell deficiency - Hepatomegaly / liver enlargement (excluding storage disease) - Lymphadenopathy / polyadenopathies - Lymphoma - Splenomegaly Occasional - Anaemia		Very frequent - Acute leukemia - Eosinophils anomalies / hypereosinophilia - Mastocytosis - Myeloproliferative syndrome / chronic leukemia